Akhundova A. A.

PATHOMORPHOLOGY

Scentific article

Abstract. Newborns with intrauterine growth retardation occupy a special place in modern neonatology, since they are susceptible to prolonged exposure to hypoxia in the intrauterine period, and this causes a severe course of various diseases of organs and systems in the early neonatal age. Kidney damage in premature infants often remains undiagnosed in the presence of other diseases such as RDS (Respiratory Distress Syndrome) and heart disorders. In our investigation, we performed a comparative analysis of the severity of kidney damage in newborns with ischemicnephropathy (IN) using KIM-1 (Kidney injury Molucule-1), NGAL ( Neuthrophil Gelatinase Associated Lipokalin) and Cystatin C biomarkers. The level of creatinine in the blood and the resistance index (RI) of the renal artery were also determined. A total of 72 newborns were included in the study. SGA (small for gestational age) newborns comprised 33, while AGA (appropriate for gestational age) newborns comprised 39 of the total number of infants. They were split into three groups based on the intensity of their IN (children with IN of I, II, or III degrees), with each group divided into two subgroups. Newborns with I degree IN (N=36) were divided into smaller subgroups of SGA (N=16) and AGA (N=20); newborns with II degree IN (N=20) were divided into SGA (N=9) and AGA (N=11); and newborns with III degree IN (N=16) were divided into SGA (N=8) and AGA (N=8) subgroups. Our results revealed that the creatinine level increased in children of the SGA subgroups with more severe degrees of IN, at a later days, while the level of KIM-1 was high at all degrees of IN, from the first days of life. The NGAL level was also higher in SGA infants with II and III degrees from the first days of life, and the Cystatin C level in the same category of infants increased only with severe IN. IR was high in all subgroups of the main group. So SGA newborns constitute a risk group for the development of acute renal injury, and early diagnosis of IN in these newborns remains one of the problems in modern medicine.

SGA infant, AGA infant, AKI (Acute Kidney Injury), Ischemic Nephropathy, KIM-1, NGAL, Cystatin C.

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«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 265-269 pages, index UDK 616.61-053.32

10.29254/2077-4214-2021-2-160-265-269