Voznyi O. V., Tsynkush R. V., Drannikov A. S.

CONDITION OF PERIODONTAL TISSUES IN ADULTS WITH DENTAL ARCH DEFECTS BEFORE AND AFTER PROSTHODONTIC TREATMENT

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About the author:

Voznyi O. V., Tsynkush R. V., Drannikov A. S.

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

The aim of the study was to determine the relationship between the concentration of biochemical markers in oral fluid and the condition of periodontal tissues in adult patients with dental defects before and after orthopedic treatment. Fifty patients were examined and divided into a main group and a control group. All participants underwent an index assessment of periodontal status, professional oral hygiene, and sanitation. In patients of the main group, the concentrations of MMP-8, sRANKL, and osteocalcin in oral fluid were additionally determined before treatment, after treatment, and one year later. The state of dental hygiene was assessed using the OHI-S index, inflammatory changes were assessed using the PMA and SBI indices, and the degree of periodontal destruction was assessed using the PI. Patients in the main group showed a significant improvement in all periodontal indicators both after treatment and one year later: the OHI-S index decreased from 3.35 to 2.00 points, the PI decreased from 1.9 to 0.4 points, the PMA decreased from 45% to 25%, and the SBI decreased from 30% to 10%. In the control group, the positive dynamics were less pronounced and not always statistically significant. The concentration of MMP-8 gradually decreased throughout the observation period (from 3.95 to 1.50 ng/ml), reflecting a decrease in the activity of inflammatory and destructive processes. Osteocalcin levels, on the contrary, increased (from 0.18 to 0.35 ng/ml), indicating the activation of bone tissue remodeling. For sRANKL, a sharp decrease was observed immediately after treatment, followed by a slight increase after 1 year, which remained below baseline values. A strong and moderate correlation was found between MMP-8 and osteocalcin, as well as between MMP-8 and the main periodontal indices at the pre-treatment stage. The results confirm the feasibility of a comprehensive assessment of clinical indices and oral fluid biomarkers to monitor the effectiveness of orthopedic treatment in patients with dental arch defects.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 412-419 pages, index UDC 616.314.2+616.314.2-089.168]:616.314.17-018

DOI:

10.29254/2077-4214-2025-4-179-412-419