Pronina O. M., Serbin S. I., Pyrog-Zakaznikova A. V., Polovik A. Yu., Rozhnov V. G.

CONTENTS

Scentific article

This paper is the fragment of research work, carried out at the Department of Emergency Medicine with Operative Surgery and Topographic Anatomy of HSEEU “UMSA”, entitled “Determination of mechanisms of morphogenesis of organs, tissues and vascular-nerve structures of the organism in norm, during experiment and under the influence of external factors. Morpho-experimental rationale of the effect of new surgical suture materials in clinical practice. ” State registration number : 0113U00124. Recent epidemiological studies show that the number of registered chronic inflammatory processes in paranasal sinuses comprise 146,0-148,°Cases per 1 thousand people. Among patients, who are receiving medical treatment at ENT in-patient departments 15-36% are patients with sinusitis. Acute rhinosinusitis is considered as inflammatory process in nasal cavity and paranasal sinuses, which lasts up to 4 weeks. Acute inflammation of paranasal sinuses, i. e., acute sinusitis, is generally associated with inflammatory changes in the nasal cavity, and, currently, is considered as common pathology, called the acute rhinosinusitis. In the USA, 1 from 7 adults experiences acute rhinosinusitis annually. In Europe acute rhinosinusitis takes the 4th place in visiting doctors of the primary health care. Thus, in our opinion, study of morphometric characteristics of structural elements of human frontal sinus mucosa is of significant practical value for current otorhinolaryngology and morphology. The purpose of research was the comparative analysis of major morphometric indices of structural elements of human septum and posterior wall of frontal sinuses in norm. Object and methods of research. Study material was the mucosa of frontal sinuses of 10 subjects, aged from 22 to 86 years old, who died of circumstances, not connected with paranasal sinus pathology. Morphometric analysis has been carried out on semi-thin sections. The results of research and their discussion. The study contains comparative analysis of morphometric data as for structural elements of human septum and posterior wall of frontal sinuses. Absence of probable differences between indices on the left and right side has been established for all studied criteria. The thickness of epithelium and proper laminar was practically similar to thickness of posterior wall and septum. The thickness of submucous layer was more on the septum by 10%, and was similar to posterior wall analogous index. Conclusions. It has been established that external diameter of terminal parts of glands was significantly smaller by 15% on the septum in comparison with posterior wall. The mean values of diameters of lumens of blood vessels of human frontal sinuses mucosa, except venules, were different at posterior wall and septum. Indices were higher on the septum. The mean diameter of veins was bigger by 35%, and mean diameter of arteries was bigger by 70% on the septum in comparison with posterior wall.

frontal sinuses, mucosa, morphometric method, human

• Автандилов Г.г. Медицинская морфометрия: Руководство / Г.г. Автандилов. – М. : Медицина, 1990. – 384 с. 2. Карупу В. Я. Электронная микроскопия / В. Я. Карупу. – Киев : Вища школа, 1984. – 207 с.
• Лапач С. Н. Статистические методы в медико-биологических исследованиях с использованием Excel + ПРИМЕРЫ: монография / С. Н. Лапач, A. B. Чубенко, П. Н. Бабич. – Киев : «МОРИОН», 2001. – 408 с.
• Новиков Д. К. Иммунология и аллергология для ЛОР-врачей / Д. К. Новиков, Л. Р. Выхристенко, П. Д. Новиков, О. В. Смирнова. – М. : МИА, 2006. – 498 c.
• Bhattacharyya N. Chronic rhinosinusitis: is the nose really involved / N. Bhattacharyya // Am. J. Rhinol. – 2001. – №15. – Р. 69-73.
• Hansen J. G. Symptoms and signs in culture-proven acute maxillary sinusitis in ageneral practice population / J. G. Hansen, T. Hшjbjerg, J. . Rosborg // APMIS. – 2009. – №117(10). – Р. 724-729.
• Kaliner M. Medical management of sinusitis / M. Kaliner // Amer. Journ. Med. Scieces. – 1998. – Vol. 316, №1. – Р. 21-28. 8. Laine K. Diagnosing acute maxillary sinusitis in primary care: a comparison of ultrasound, clinical examination and radiogra-
• phy / K. Laine, T. Maatta, H. Varonen, M. Makela // Rhinology. – 1998. – №36. – Р. 2-6.
• Lethbridge-Cejku M. Sum-mary health statistics for U. S. Adults. National Health Interview Survey, 2004 / M. Lethbridge-Cejku, D. Rose, J. Vickerie // National Center for Health Statistics. Vital Health Stat. – 2006. – №10(228). – Р. 19–22.
• Lynn J. Rapid toluidine blue staning of Epon-embeded and mounted “adjactnt” sections / J. Lynn // Am. J. Clin. Path. – 1965. – №44. – H. 57 – 58.
• Meltzer E. O. Rhinosinusitis: establishing definitions for clinical research and patient care / E. O. Meltzer, D. L. Hamilos, J. A. Hadley [et al.] // Otolaryngol. Head Neck Surg. – 2004. – №131(Suppl). – Р. 1-62.
• Snow V. Principles of appropriate antibiotic use for acute sinu-sitis in adults / V. Snow, C. Mottur-Pilson, J. M. Hickner // Ann. Intern. Med. – 2001. – №134. – Р. 495–497.
• Unsworth L. Trends in primary care antibiotic prescribing in England 1994-1998 / L. Unsworth, T. Walley // Pharmacoepide-miol. Drug Saf. – 2001. –№10. –Р. 309-314.

«Bulletin of problems biology and medicine» Issue 2 part 2 (108), 2014 year, 098-101 pages, index UDK 611. 21