Derbak M. A., Motylchak E. M., Khramtsova I. O., Zhovanyk N. B.

CLINICAL DIFFERENCES OF GASTROINTESTINAL DISORDERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA

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About the author:

Derbak M. A., Motylchak E. M., Khramtsova I. O., Zhovanyk N. B.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The article presents a comparison of the frequency, structure, and clinical differences of gastrointestinal (GI) disorders caused by gastroesophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), and analyzes their impact on the course of the primary disease. It was found that GI disorders occur significantly more frequently in patients with BA compared to those with COPD (60% vs. 45%, p < 0.05) and are typical for esophageal reflux: classic heartburn and acid regurgitation. In pa tients with COPD, atypical gastrointestinal symptoms were more commonly recorded: chronic cough without heart burn, a feeling of gastric fullness, belching, and hoarseness. It was established that the presence of GI symptoms in both patient groups is associated with a worsening of the primary disease’s course; however, this association is more pronounced in patients with COPD. In the COPD group, the presence of GI symptoms was associated with a significant increase in the risk of exacerbations (OR 2.1-5.3; p<0.01). In the BA group, a moderately increased risk of nocturnal attacks was observed (OR 1.3-1.5; p<0.05). The results obtained underscore the importance of screening for gastrointestinal symptoms in patients of both groups to optimize treatment and prevent exacerbations.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 1, 180, 214-221 pages, index UDC 616.24-007.272+616.248]:616.333-008.6

DOI:

10.29254/2077-4214-2026-1-180-214-221