Khmil S. V., Krotik S. S.

CHRONIC ENDOMETRITIS AS A CAUSE OF REPRODUCTIVE FUNCTION DISORDERS IN WOMEN (LITERATURE REVIEW)

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About the author:

Khmil S. V., Krotik S. S.

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LITERATURE REVIEWS

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Scientific article

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The article presents current data on the optimization of cryoprotocols in patients with infertility of unknown genesis in the setting of chronic endometritis (CE). This inflammatory endometrial disease significantly affects reproductive function. CE is associated with embryo implantation failures, reducing endometrial receptivity, which leads to a decrease in the effectiveness of in vitro fertilization cycles. The disease is of significant medical and social importance due to its increasing prevalence and difficulties in treatment, which worsen patients' quality of life. The study aims to summarize current scientific data, including clinical guidelines, randomized trials, and recommendations, to improve the diagnosis and treatment of CE in women with infertility. The article describes the pathophysiological mechanisms of the development of CE, including increased levels of proinflammatory cytokines and endometrial microflora disorders. The use of modern diagnostic methods, such as immunocytochemical detection of CD138+ plasma cells and PCR, provides an accuracy of CE of up to 90%, significantly reducing the risk of false negative results. Therapeutic approaches include antibiotic therapy with doxycycline and metronidazole, probiotics to normalize the microflora, and immunomodulators to restore endometrial function. The integration of these methods can significantly reduce the frequency of failed IVF attempts and increase the chances of a successful pregnancy. It is concluded that improving diagnostic approaches and therapeutic strategies is a key factor in improving the effectiveness of infertility treatment. Optimizing cryoprotocols in patients with infertility of unknown genesis in the setting of chronic endometritis is a multifactorial process that includes correcting the endometrial condition, individualizing treatment, and improving laboratory methods. This can improve the results of assisted reproductive technology programs and increase the pregnancy rate. Further research is needed to determine optimal therapeutic protocols and long-term outcomes.

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 154-161 pages, index UDC 618.145-002-036.12-06:618.17-089.888.11(048.8)

DOI:

10.29254/2077-4214-2024-4-175-154-161