Sodomora О. О.

MORPHOLOGY

Scentific article

Background. Monosodium glutamate is a food additive and flavor enhancer that is widely used and has been considered relatively safe for consumption in many countries. For the duration of its use in food industry monosodium glutamate has raised concern in researches and health professionals due to its reported toxic effects on the structure and function of internal organs, especially in prolonged oral consumption. Numerous scientific research studies have reported various toxic effects of monosodium glutamate that manifested in structural and morphologic changes of organs and tissues resulting in their functional impairment. However, further studies are needed to establish monosodium glutamate role in pathologic changes of vascular morphology due to somewhat controversial scientific data presently available and certain limitations arising when it comes to implication of experimental studies’ results in clinical practice, given the various design of the animal studies, as well as different ways of monosodium glutamate administration used in them, proving it hard to extrapolate some results on human population. Objective. The objective of this study was to analyze morphologic changes of carotid sinus at the early stages of monosodium glutamate oral administration in experimental setting. Materials and methods. Carotid sinuses of 10 adult male white laboratory rats were subjected to morphologic studies (preparation, corrosion, histology) following 4 weeks of oral administration of 10 mg/kg monosodium glutamate daily. The data was compared with the results of morphologic study of carotid sinus in the control group of 10 adult male rats. Conclusions. The data obtained points towards the fact that systematic oral administration of monosodium glutamate may induce structural changes of carotid sinus, carotid glomus and carotid arteries wall even at early stages of consumption, which may result in brain perfusion compromise, as well as in functional impairment of carotid glomus. Further investigation is needed to establish the fact and degree of structural impairment of carotid sinus in prolonged monosodium glutamate use, as well as to evaluate morphologic changes associated with monosodium glutamate withdrawal.

monosodium glutamate, carotid sinus, carotid glomus, internal carotid artery, carotid bifurcation.

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«Bulletin of problems biology and medicine» Issue 2 Part 2 (165), 2022 year, 156-164 pages, index UDK 612.014.46:547.466.64:611.133]-08

10.29254/2077-4214-2022-2-2-165-156-164