Denysenko V. D., Rozhnov A. S.

BIORESORBABLE MEMBRANES FOR GUIDED BONE REGENERATION BASED ON POLYURETHANE UREAS

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About the author:

Denysenko V. D., Rozhnov A. S.

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METHODS AND METHODOLOGIES

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Scientific article

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Modern regenerative medicine is actively investigating biocompatible materials for stimulating the growth and repair of bone tissue. Polyurethane ureas (PUUs) exhibit high mechanical strength, biocompatibility, and controlled biodegradation, making them suitable for the development of membranes in guided bone regeneration (GBR). The biodegradation of PUUs was studied through changes in mechanical properties and structure over 1, 3, and 6 months of incubation in biological medium 199. According to IR spectroscopy data, structural changes in PUUs are observed in the biological environment in the νNH region (3308 cm⁻¹ and 3500 cm⁻¹), indicating the disruption or redistribution of hydrogen bonds. A decrease in the intensity of the νC=O (1726 cm⁻¹) and δNH (1535 cm⁻¹) bands suggests hydrolysis of urethane and urea bonds. The appearance of an absorption band at ~1650 cm⁻¹ indicates destructive changes in the polymer chain and alterations in hydrogen bonding. The obtained results confirm that the polymer actively interacts with the biological medium, leading to its partial degradation and structural modification. According to physical-mechanical testing, PUUs lose tensile strength after 6 months of incubation, indicating biodeg radation and ensuring a sufficient functional lifespan of membranes during bone regeneration. Cytotoxicity studies using fibroblast tissue culture revealed no adverse effects of PUUs on cell growth and development, confirming their safety for biomedical applications. Therefore, PUUs are a promising material for bioresorbable membranes in max illofacial surgery, combining effective mechanical support with controlled degradation and no negative impact on surrounding tissues.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 343-355 pages, index UDC 616.31-089.843:678.664.4-022.532

DOI:

10.29254/2077-4214-2025-2-177-343-355