Holopiorova V., Nosenko V., Moskalenko R.

LITERATURE REVIEWS

Scentific article

Introduction. The increase in the number of respiratory lesions in the context of the COVID-19 pandemic and the tuberculosis epidemic leads to many complications, including calcification or pathological lung biomineralization (PBL). Respiratory remodeling caused by fibrosis and concomitant calcification is an important pathogen in chronic obstructive pulmonary disease (COPD) and subsequent chronic respiratory failure. The work aims to conduct bibliometric analysis and generalization of data from scientific sources to study the role of pathological biomineralization of lung tissue. Materials and methods. The authors searched for information in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar, in the key terms «pathological lung biomineralization» «lung calcification.» For bibliometric analysis, an online platform for monitoring and analysis of international research using visualization tools and modern citation metrics SciVal (Scopus) and a tool for building and visualizing bibliometric networks VOSviewer were used. Results. Pathological mineralization of the lungs is a multifactorial phenomenon: hypercalcemia, change of acid-base state in the alkaline direction, damage to lung tissue by infectious agents, genetic heredity. The danger of pathological biomineralization of the lungs is the gradual invisible occurrence of respiratory failure. We conducted a bibliometric analysis of the scientific literature. The number of publications on PBL has increased significantly over the past 10 years. Scientists from the United States, Japan, China, and India occupy the leading positions in this area. Analysis of publishing activity using the VOSviewer bibliometric network visualization tool for 1946-2022 by keywords showed the presence of 4 chronological publication stages. Among the 1356 publications analyzed, the most relevant areas of publishing activity are works on PBL in malignant neoplasms and tuberculosis, current radiological diagnosis of PBL, an association of PBL with inflammation and osteoporosis, biomarkers and biomaterials associated with PBL

pathological lung biomineralization, calcification, bibliometry, SciVal.

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«Bulletin of problems biology and medicine» Issue 1 (163), 2022 year, 15-21 pages, index UDK 616.24-003.84-091.8:001.891

10.29254/2077-4214-2022-1-163-15-21