Slyusar N. А.

ASSESSMENT OF QUALITY OF LIFE IN CHILDREN WITH FUNCTIONAL GASTROINTESTINAL DISORDERS ACCOMPANIED BY ABDOMINAL PAIN DURING MARTIAL LAW

---

Show/Download

About the author:

Slyusar N. А.

Heading:

PEDIATRICS

Type of article:

Scientific article

Annotation:

The high prevalence of functional gastrointestinal disorders in children (19-40%) significantly reduces their quality of life due to the complex pathophysiology conceptualized in the biopsychosocial model with the interaction of visceral hypersensitivity, psychoemotional disorders (e.g., anxiety), and social factors. In Ukraine, the relevance of functional gastrointestinal disorders is exacerbated by the ongoing military conflict, which is confirmed by the high prevalence of post-traumatic stress disorder (44%) and the increase in psychosomatic disorders in children, deter- mining the key role of multidimensional assessment of quality of life to identify problem areas. The aim is to assess the quality of life in children with functional gastrointestinal disorders accompanied by abdominal pain under martial law. The study included 176 children aged 6-17 years with functional gastrointestinal disorders accompanied by abdominal pain (main group). The control group consisted of 30 practically healthy children of the appropriate age. The Ukrainian version of the international standardized questionnaire Pediatric Quality of Life Inventory™ (PedsQL™) 4.0 was used to assess the quality of life. The following indicators were analyzed in all study participants: total quality of life score, total scores of physical and psychosocial health. Significantly lower total scores of physical health, psychosocial health and total quality of life were found in children with functional dyspepsia and irritable bowel syndrome compared to the control group (p < 0.05). A negative strong rank correlation was found between all analyzed quality of life indicators and the intensity of abdominal pain (assessed by a visual analog scale), as well as the level of anxiety (determined using the children's version of the SCARED-C scale (Screen for Child Anxiety Related Emotional Disorders, Child Version)). Research on quality of life is an important component of a comprehensive assessment of the condition of children with functional gastrointestinal disorders accompanied by abdominal pain. This methodology is of particular importance in conditions of martial law, since it allows you to determine the degree of impact of the pathology on social adaptation, academic performance and educational functioning of the child.

Tags:

Bibliography:

1. Sliusar NA, Volosovets OP, Kryvopustov SP, Saltanova SD. Vplyv neirotransmiteriv na perebih funktsionalnykh hastrointestynalnykh rozladiv, asotsiiovanykh z porushenniamy emotsiino-volovoi sfery, shcho obumovleni stresom, u ditei. Zdorovia dytyny. 2024;19(4):50-60. [in Ukrainian].
2. Zeevenhooven J, Zeevenhooven L, Biesbroek A, Schappin R, Vlieger AM, van Sleuwen BE et al. Functional gastrointestinal disorders, quality of life, and behaviour in adolescents with history of infant colic. Acta Paediatr. 2024;113(6):1435-1443. DOI: 10.1111/apa.17215.
3. Bielousova OIu, Zimnytska TV, Kazarian LV. Otsinka yakosti zhyttia v ditei iz poiednanniam funktsionalnoi dyspepsii ta syndromu podraznenoho kyshechnyka. Suchasna pediatriia. Ukraina. 2023;1(129):23-27. DOI: 10.15574/SP.2023.129.23. [in Ukrainian].
4. Brodwall A, Brekke M. Children’s and adolescents’ experiences with functional abdominal pain: a qualitative study in Norway. BMJ Open. 2021;11(9):e048949. DOI: 10.1136/bmjopen-2021-048949.
5. Volosovets OP, Кryuchko TO, Marushko YuV, Shadrin OН, Volosovets TM, Pochynok TV, et al. Pathomorphosis of diseases of the digestive system allergic and non-allergic genesis in children of Ukraine in the dynamics of 25 years of observation. World of medicine and biology. 2022;3(81):40-45. DOI: 10.26724/2079-8334-2022-3-81-40-45.
6. Vernon-Roberts A, Alexander I, Day AS. Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria). J. Clin. Med. 2021;10(21):5087. DOI: https://doi.org/10.3390/jcm10215087.
7. Legeret C, Stienen Y, Furlano R, Kohler H. Effectivity of treatment for children with functional dyspepsia. Sci Rep. 2022;12(1):1467. DOI: 10.1038/s41598-022-05380-y.
8. Sliusar NA, Kryvopustov SP. Rol serotoninu ta melatoninu u rozvytku klinichnykh proiaviv funktsionalnykh shlunkovo-kyshkovykh rozladiv, poviazanykh z bolem u zhyvoti u ditei u voiennyi chas. Zdorovia dytyny. 2025;20(4):247-253. DOI: https://doi.org/10.22141/2224-0551.20.4.2025. 1845. [in Ukrainian].
9. Skovslund Nielsen E, Kallesoe K, Bennedsen Gehrt T, Bjerre-Nielsen E, Lalouni M, Frostholm L, et al. Trajectories of Change, Illness Understanding, and Parental Worries in Children and Adolescents Undergoing Internet-Delivered Cognitive-Behavioral Therapy for Functional Abdominal Pain Disorders: Protocol for a Single-Case Design and Explorative Pilot Study. JMIR Res Protoc. 2025;14:e58563. DOI: 10.2196/58563.
10. Ukrinform. Indeks maibutnoho (Indeks dobrobutu ditei). Ukrinform; 2024. Dostupno: https://www.ukrinform.ua/rubric-society/3833388- riven-dobrobu tu -ditej-v-ukraini-visij-serednogo.html. [in Ukrainian].
11. Antypkin YuH, Kyrylova LH, Miroshnykov OO, Yuzva OO, Berehela OV. Stres-indukovani rozlady v ditei z porushenniamy neirorozvytku v period voiennoho chasu i pidkhody do yikh korektsii. Mizhnarodnyi nevrolohichnyi zhurnal. 2023;19(5):29-36. [in Ukrainian].
12. Volosovets OP, Vyhovska OV, Kryvopustov SP, Mozyrska OV, Yemets OV, Volosovets AO, et al. Problems of providing medical care to children of Ukraine as a result of russian aggression. Child`s Health. 2023;18(3):9-13. DOI: https://doi.org/10.22141/2224-0551.18.3.2023.1578.
13. Volosovets ОP, Kryuchko TO, Chernyshova OE, Volosovets AО, Trachuk LE, Guryev SO, et al. Changes in the morbidity and prevalence of mental and behavioral disorders of children living in the warzone in eastern Ukraine. World of medicine and biology. 2021;2(76):12-17. DOI: 10.26724/2079-8334-2021-2-76-12-17.
14. Karami H, Lashtoo Aghaee B, Yazdani Charati J, Abedi A. Quality of Life for Children With Functional Abdominal Pain and Their Parents Copmared to Healthy Individuals. J. Pediatr. Rev. 2022;10(3):267-272. Available from: http://jpr.mazums.ac.ir/article-1-439-en.html.
15. Walker R, Cornish M, Knott G, Kammermeier J, Vora R, Mutalib M. G26 Detailed analysis of PEDSQL results can more accurately assess impact of functional gastrointestinal disorders on quality of life in paediatric patients and their families. Frontline Gastroenterology. 2022;13:A33-A34.
16. Allahverdi B, Rahmani Ahranjani P, Alimadadi H, Asgar Shirazi M, Amini A. Investigating the Quality of Life of Children and Adolescents with Irritable Bowel Syndrome. Journal of Pediatric Perspectives. 2025;13(2):19316-19324. DOI: 10.22038/jpp.2025.86008.5524.
17. Kuchyn YuL, Naumenko OM, Yavorovskyi OP, Skaletskyi YuM, Brukhno RP, Zinchenko TO, ta in. Do pytannia zabezpechennia bezpechnoho zastosuvannia likarskykh zasobiv. Materialy Naukovo-praktychnoi konferentsii z mizhnarodnoiu uchastiu do Vsesvitnoho dnia bezpeky patsiientiv Bezpeka patsiientiv v Ukraini: liky bez shkody; 2022 Ver 16; Kyiv. Kyiv: MVTs «Medinform»; 2022, s. 16-22. [in Ukrainian].
18. Sliusar NA, Saltanova SD. Klinichnyi perebih funktsionalnykh hastrointestynalnykh rozladiv, shcho suprovodzhuiutsia abdominalnym bolem, u ditei v umovakh voiennoho stanu. Visnyk problem biolohii i medytsyny. 2024;3(174):374-385. DOI: 10.29254/2077-4214-2024- 3-174-374-385. [in Ukrainian].
19. Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, Tilburg M. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology. 2016;150(6):1456-68. DOI: 10.1053/j.gastro.2016.02.015.
20. Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care. 2001;39(8):800-12. DOI: 10.1097/00005650-200108000-00006.
21. KandaY. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Trans-plant. 2013;48(3):452-8. DOI: 10.1038/bmt.2012.244.
22. Sjolund J, Kull I, Bergstrom A, Ljotsson B, Tornblom H, Olon O, et al. Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome From Adolescence to Adulthood. Clin Gastroenterol Hepatol. 2024;22(4):858-866.e6. DOI: 10.1016/j.cgh.2023.09.022.
23. Trindade IA, Melchior C, Tornblom H, Simren M. Quality of life in irritable bowel syndrome: Exploring mediating factors through structural equation modelling. J Psychosom Res. 2022;159:110809. DOI: 10.1016/j.jpsychores. 2022.110809.
24. Lee SW, Yang CM, Ryu HS, Choi SC, Lee SY, Jang SH. Psychological Characteristics and Quality of Life of Patients with Functional Dyspepsia. Psychiatry Investig. 2024;21(6):637-645. DOI: 10.30773/pi.2024.0079.
25. Govindasamy V, Mashayekhi Y, Khan MN, Olakunori-Ovaga OJ, Kumar N, Zafar M, et al. Association Between Gastrointestinal Symptoms and Anxiety Levels in Patients with Functional Dyspepsia. Cureus. 2025;17(5):e84810. DOI: 10.7759/cureus.84810.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 470-482 pages, index UDC 616.33-009.7:616.34-009]-056.2-07-053.2:303.522]](477)"364"

DOI:

10.29254/2077-4214-2025-3-178-470-482