Chystyakova E. Ye., Smolenko N. P., Korenyeva Ye. M., Velychko N. F., Belkina I. O., Marahovskiy I. O., Bondarenko V. A.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Inflammation of the prostate gland is the most common in men of reproductive age and can cause erectile dysfunction and infertility. Prostatilen is used as a prostate protector, which has a specific organotropic effect on the pancreas. However, the effect of Prostatilen on sexual behavior, features of spermatogenesis, fertility and fertility has not been studied, which was the aim of the study. Simulation of chronic prostatitis (ChP) in rats was performed by irrigating the ventral part of the prostate with the pharmaceutical agent Wartner® (group ChP). Improperly operated rats (Control group) served as controls. For the correction of ChP was chosen the drug Prostatilen, which is rectally once a day, starting from the 15th day after surgery for three weeks (group ChP+Pr). After correction, sexual behavior was examined; male fertility and fertility; serum testosterone concentration. Correction of ChP with Prostatilen in comparison with the data of animals of the ChP group led to an increase in the number of intromissions during the test by 3.3 times; increase in the number of rats that ejaculated (two of which started the second series of mating); increase in the total concentration of sperm by 43% and the integrated indicator of CN by 52%, the number of motile sperm by 36% and a decrease in the proportion of pathological forms of gametes twice; increase in total testosterone by 46 %; improving fertility and fertility (reducing pre-implantation embryo death by almost twice). Thus, experimental prostatitis in male rats leads to erectile dysfunction; accompanied by impaired spermatogenesis; a decrease in the concentration of total testosterone, and, as a consequence, there is a decrease in fertility and fertility. The use of Prostatilen improves the reproductive function of males with experimental prostatitis, namely: normalizes sexual behavior and spermatogenesis, restores androgenic status, resulting in restored fertility and fertility of animals.

experimental prostatitis, Prostatilen, sexual behavior, spermogram, fertility.

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«Bulletin of problems biology and medicine» Issue 3 (161), 2021 year, 163-167 pages, index UDK 612.615+591.463.12

10.29254/2077-4214-2021-3-161-163-167