Ostrovska S. S., Muntian. S. O., Komskyi M. P., Antonova O. V., Gerasimchuk P. G., Yevtushenko T. V., Makarets M. F.

APPLICATION OF NATURAL DIETARY ANTIOXIDANTS OF VEGETABLE ORIGIN TO REDUCE CADMIUM INTOXICATION (REVIEW OF FOREIGN LITERATURE)

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About the author:

Ostrovska S. S., Muntian. S. O., Komskyi M. P., Antonova O. V., Gerasimchuk P. G., Yevtushenko T. V., Makarets M. F.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

Environmental pollution with the heavy metal cadmium (Cd). is widely studied due to the fact that more and more evidence appears in scientific sources regarding its negative impact on human health. The main pathological effect is considered to be Cd-induced hyperproduction of reactive oxygen species with subsequent oxidative stress (OS), which leads to the occurrence of many pathological changes in the body. In this regard, the scientific community is actively searching for substances that counteract such disorders, and one of them is substances with antioxidant properties. In this review, a group of natural substances of plant origin, capable of counteracting OS caused by Cd, was studied. Experimental and clinical studies have shown that ascorbic acid, rutin, quercetin, N-acetyl-1-cysteine, resveratrol, epigallocatechin-3-gallate, isocyanate are able to influence various links of the metabolic process, weakening the effect of Cd-induced OS. These studies are important for their use in preventive and therapeutic purposes in the form of dietary antioxidants, having a scientific theoretical basis. Pharmacological effects of improvement of vascular dysfunction and Cd-induced hypertension under the action of vitamin C are given in the review. The role of OS in the development of cancer, the negative impact on energy metabolism and epigenetic regulation of microRNAs is widely discussed in the literature. The role of rutin hydrate against Cd-induced neurotoxicity and cognitive impairment in rats was investigated. Rutin has been shown to alleviate Cd-mediated cognitive impairment. due to the limitation of apoptosis pathways, as well as the recovery of brain damage and memory impairment. Administration of quercetin prevented the development of steatosis and liver fibrosis in rats by suppressing the expression of miRNA-21. N-acetyl-1-cysteine effectively resists increased invasiveness of tumor cells, Resveratrol weakens epigenetic changes caused by exposure to Cd. The green tea antioxidant epigallocatechin-3-gallate counteracts Cd-induced mitotoxicity, mitochondrial lipid peroxidation, and has anticancer properties in humans. The use of natural plant antioxidants has great prophylactic and therapeutic prospects for diseases based on oxidative stress.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 84-91 pages, index UDC 612.014.466546.48:616-085542.943:615.32

DOI:

10.29254/2077-4214-2024-4-175-84-91