Kaleynikova O. M., Sribna V. O., Vinohradova-Anik O. O., Lytvynenko A. P., Blashkiv T. V., Voznesenska T. Yu.
APOPTOTIC AND NON-APOPTOTIC DEATH OF EPIDIDYMAL SPERMATOZOA UNDER IN VITRO OXIDATIVE STRESS
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About the author:
Kaleynikova O. M., Sribna V. O., Vinohradova-Anik O. O., Lytvynenko A. P., Blashkiv T. V., Voznesenska T. Yu.
Heading:
PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH
Type of article:
Scientific article
Annotation:
Oxidative stress is a key pathogenetic factor leading to impaired spermatogenesis and, consequently, to reduced fertility and impairment of male reproductive health. The aim of the work was to investigate the effects of substances that increase the generation of free radicals (H₂O₂), particularly their concentration, on the viability of epididymal spermatozoa in order to model oxidative stress in vitro. Results: under conditions of oxidative stress (both “moderate” and “severe”), there is a decrease in viable cells and an increase in apoptotic, necrotic, and autophagic spermatozoa.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 35-37 pages, index UDC 612.015.3:612.617:577.27
