ANTIBIOTIC SENSITIVITY OF MICROORGANISMS OBTAINED FROM VARIOUS SOURCES AT BONADEA HOSPITAL IN BAKU

Guliyeva M. Z., Mutalibova N. F.

ANTIBIOTIC SENSITIVITY OF MICROORGANISMS OBTAINED FROM VARIOUS SOURCES AT BONADEA HOSPITAL IN BAKU


Show/Download

About the author:

Guliyeva M. Z., Mutalibova N. F.

Heading:

MICROBIOLOGY

Type of article:

Scientific article

Annotation:

Nosocomial infections reduce the effectiveness of patient treatment and increase the number of hospitalizations, which leads to further growth of treatment costs and serious economic losses. Given the rapid growth of antibiotic resistance of microorganisms, many unsolved problems remain in the field of antibiotic therapy of nosocomial infections. The article studies the etiological structure and antibiotic resistance of pathogens isolated from abiotic sources and from patients of Bonadea Hospital. Bacteriological examination of 22 samples taken from surfaces surrounding patients and from equipment used in the intensive care unit of Bonadea Hospital, 5 air samples from the rooms where patients were located, as well as from the hands of 4 patients treated in the intensive care unit was carried out. During the study, Escherichia coli bacteria were detected in 5 of 22 samples (22.7%), including samples taken from 3 aspirators and 2 oxygen therapy devices. Bacteriological examination of air samples did not reveal any bacteria. The detection of E.coli in surface samples from aspirators indicated improrer sanitary conditions in the intensive care unit. Phage typing with coliphage revealed the intraspecific identity of E.coli in all samples taken from the surface of aspirators and indicated contamination from a single source of infection. In order to develop a set of anti-epidemic measures to prevent the development and exacerbation of the epidemic process in a hospital setting, it is necessary to identify epidemiological markers, as well as develop and implement antimicrobial therapy management programs aimed at reducing the use of antibiotics and their rational use.

Tags:

antibiotics resistance, nosocomial infections

Bibliography:

  1. European Centre for Disease Prevention Control. Surveillance of antimicrobial resistance in Europe 2018. Stockholm: European Centre for Disease Prevention Control; 2019. 110 p. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/surveillance-antimicrobial-resistance-Europe 2018.
  2.  Cassini A, Plachouras D, Eckmanns T, Abu Sin M, Blank HP, Ducomble T, et al. Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study. PLoS Med. 2016;13(10):e1002150. DOI: 10.1371/journal.pmed.1002150.
  3.  GBD 2019 Antimicrobial Resistance Collaborators, et al. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022;400(10369):2221-2248. DOI: 10.1016/S0140-6736(22)02185-7.
  4.  Weiner LM, Webb AK, Limbago B, Dudeck MA, Patel J, Kallen AJ, et al. Antimicrobial-Resistant Pathogens Associated With Healthcare Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control andPrevention, 2011-2014. Infect Control Hosp Epidemiol. 2016;37(11):1288-1301
  5. Cerceo E, Deitelzweig SB, Sherman BM, Amin AN. Multidrug-resistant gram-negative bacterial infections in the hospital setting: overview, implications for clinical practice, and emerging treatment options. Microb. Drug Resist. 2016;22(5):412-31.
  6.  Mancuso G, Midiri A, Gerace E, Biondo C. Bacterial antibiotic resistance: the most critical pathogens Pathogens. 2021;10:1310.
  7. Deshpande A, Cadnum JL, Fertelli D, Sitzlar B, Thota P, Mana TS. Are hospital floors an underappreciated reservoir for transmission of health care-associated pathogens ? Am J Infect Control. 2017;45(3):336-8.
  8.  MacVane SH. Antimicrobial resistance in the intensive care unit: a focus on gram-negative bacterial infections. J. Intensive Care Med. 2017;32(1):25-37.
  9.  Shinagawa N, Taniguchi M, Hirata K, Furuhata T, Fukuhara K, Mizugucwi T, et al. Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents-special references to bacteria isolated between April 2010 and March 2011. Jpn J Antibiot. 2014;67(5):293-334.
  10.  Wahid B, Tiwana MS. Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics. Future Microbiol. 2024;19(9):811-824.
  11.  Daubie V, Chalhoub H, Blasdel B, Dahma H, Merabishvili M, Glonti T, et al. Determination of phage susceptibility as a clinical diagnostic tool: A routine perspective. Front Cell Infect Microbiol. 2022;12:1000721. DOI: 10.3389/fcimb.2022.1000721.
  12.  Ny S, Edquist P, Dumpis U, Gröndahl-Yli-Hannuksela K, Hermes J, Kling AM, et al. Antimicrobial resistance of Escherichia coli isolates from outpatient urinary tract infections in women in six European countries including Russia. J Glob Antimicrob Resist. 2019;17:25-34. DOI: 10.1016/j.jgar.2018.11.004.
  13.  Goswami C, Fox S, Holden MTG, Connor M, Leanord A, Evans TJ. Origin, maintenance and spread of antibiotic resistance genes within plasmids and chromosomes of bloodstream isolates of Escherichia coli. Microbial Genomics. 2020;6(4):1-17.
  14.  Choi YK, Byeon EJ, Park JJ, Lee J, Seo YB. Antibiotic Resistance Patterns of Enterobacteriaceae Isolated from Patients with Healthcare-Associated Infections. Infect Chemother. 2021;53(2):355-363. DOI: 10.3947/ic.2021. 0030.
  15.  Saeed S, Samala S, Rengan R. The “blue moon” of respiratory tract infections: Escherichia coli pneumonia. Chest Infections. 2021;160(4):450-455.
  16.  Schneer S, Khoury J, Adir Y, Stein N, Shaked Mishan P, Ken-Dror S, et al. Clinical characteristics and outcomes of patients with Escherichia coli in airway samples. Clin Respir J. 2020;14(3):205-213. DOI: 10.1111/crj.13116.
  17.  La Fauci V, Costa GB, Facciolà A, Conti A, Riso R. Squeri.Humidifiers for oxygen therapy: what risk for reusable and disposable devices? J Prev Med Hyg. 2017;58(2):161-165.
  18.  Huang LJ, Chen SJ, Hu YW, Liu CY, Wu PF, Sun SM, et al. The impact of antimicrobial stewardship program designed to shorten antibiotics use on the incidence of resistant bacterial infections and mortality. Sci Rep. 2022;12(1):913. DOI: 10.1038/s41598-022-04819-6.

Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 376-382 pages, index UDC 616:579.61

DOI:

10.29254/2077-4214-2025-2-177-376-382

Was this article helpful?

Leave a Reply

Your email address will not be published. Required fields are marked *


The reCAPTCHA verification period has expired. Please reload the page.