Kozyolkin O. A., Kuznietsov A. A.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. Aim of the study was to evaluate informativeness of serum interleukin 6 and interleukin 10 in detecting of short-term prognosis in patients in acute period of spontaneous supratentorial intracerebral hemorrhage on the ground of conservative treatment. Materials and methods. Prospective cohort comparative study was done that included 104 patients with SSICH. Diagnosis was made by using clinical neurovisualization investigation. Serum interleukin 6 and interleukin 10 concentrations were measured with immunoassay analysis. Unfavorable variants of spontaneous supratentorial intracerebral hemorrhage course and outcome on the ground of conservative treatment were considered as end points. Statistical data processing was performed with Statistica 13.0 and MedCalc (version 18.2.1) using logistic regression analysis, ROC-analysis and correlation analysis. Results. Patients with unfavorable spontaneous supratentorial intracerebral hemorrhage course and outcome on the 1st day of admission were characterized with higher serum levels of interleukin 6 and interleukin 10 that correlated with brain injury severity. High sensitive multipredictive models that integrate prognostic value of serum interleukin 6 level with informativeness of clinical neurovisualization parameters during 1st day of admission are elaborated on the ground of logistic regressive analysis. These models allow to predict unfavorable variants of spontaneous supratentorial intracerebral hemorrhage acute period outcome on the ground of conservative treatment with accuracy >85,0% (AUC>0,90). Conclusions. Initial level of interleukin 6 in serum of patients with spontaneous supratentorial intracerebral hemorrhage in comparison with interleukin 10 are more informative indicators for short-term disease prognosis on the ground of conservative treatment.

intracerebral hemorrhage, interleukin 6, interleukin 10, prognosis.

1. Weimar C, Kleine-Borgmann J. Epidemiology, Prognosis and Prevention of Non-Traumatic Intracerebral Hemorrhage. Current Pharmaceutical Design. 2017;23(15):2193-2196. doi: 10.2174/1381612822666161027152234.
2. de Oliveira Manoel AL. Surgery for spontaneous intracerebral hemorrhage. Crit Care. 2020;24(1):45. doi: 10.1186/s13054-020-2749-2.
3. An SJ, Kim TJ, Yoon BW. Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. J Stroke. 2017;19(1):3-10. doi: 10.5853/jos.2016.00864.
4. Wilkinson DA, Pandey AS, Thompson BG, Keep RF, Hua Y, Xi G. Injury mechanisms in acute intracerebral hemorrhage. Neuropharmacology. 2018;134:240-248. doi: 10.1016/j.neuropharm.2017.09.033.
5. Tschoe C, Bushnell CD, Duncan PW, Alexander-Miller MA, Wolfe SQ. Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets. J Stroke. 2020;22(1):29-46. doi: 10.5853/jos.2019.02236.
6. Zhang Z, Zhang Z, Lu H, Yang Q, Wu H, Wang J. Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage. Mol Neurobiol. 2017;54(3):1874-1886. doi:10.1007/s12035-016-9785-6.
7. Lan X, Han X, Li Q, Yang QW, Wang J. Modulators of microglial activation and polarization after intracerebral haemorrhage. Nature Reviews Neurology. 2017;13(7):420-433. doi: 10.1038/nrneurol.2017.69.
8. Ouyang W, O’ Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation. Immunity. 2019;50(4):871-891. doi: 10.1016/j.immuni.2019.03.020.
9. Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspectives in Biol. 2014;6(10):a016295. doi: 10.1101/cshperspect.a016295.
10. Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease [published correction appears in Nat Immunol. 2017 Oct 18;18(11):1271]. Nat Immunol. 2015;16(5):448-457. doi: 10.1038/ni.3153.
11. Garcia JM, Stillings SA, Leclerc JL, Phillips H, Edwards NJ, Robicsek SA, et al. Role of Interleukin-10 in Acute Brain Injuries. Front Neurol. 2017;8:244. doi: 10.3389/fneur.2017.00244.

«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 80-87 pages, index UDK 616.831-005.1-036.11-021.3-037:612.017.1.014

10.29254/2077-4214-2021-1-159-80-87