Ostrovska L. Y., Moshel T. N., Ivanytskiy I. O.

DENTISTRY

Scentific article

The paper presents the study of ten integrated haematological indicators indices in patients with generalized periodontitis (GP) combined with chronic cholecystitis course (CC) and pancreatitis (CP) and in pregnant women with inflammatory changes in periodontal tissues in different trimesters of pregnancy. It has been found that patients with GP with combined course of CC and CP display a significant increase in leukocyte index (LI) by 1.28 times (p < 0.001), reflecting the relationship between the humoral and cellular links of the immune system. The index value of leukocytes and erythrocyte sedimentation rate (IL ESR) confirmed the presence of intoxication. It was increased by 3.4 times (p < 0.001) as compared to IL ESR in healthy individuals. This probably indicates infectious and autoimmune nature of the pathological process in patients with GP against the background of CC and CP which is more significantly manifested in patients with GP of II severity degree. A statistically significant difference was obtained during the determination of hematological and other indices. Thus, the value of lymphocyte granulocyte-index (ILH) was increased by 1.2 times (p < 0.05). The index value of neutrophils and monocytes (ISNM) was increased by 3.5 times (p < 0.01) which reflects the ratio of components of the microphage-macrophage system. The index of the ratio between neutrophils and lymphocytes (ISNL) was slightly reduced 1.2 times (p < 0.05) as compared with healthy individuals, reflecting the ratio of specific and non-specific cell protection. Analysis of hematological parameters in dynamics of pregnancy showed that leukocyte intoxication index (LII) in the first trimester of patients in the control group was 1.81 ± 0.07 (p < 0.05), which is by 1.8 times more than the donors. Besides, the increase of LII of 6.7% was noted by the third trimester. This dynamics suggests the growth of endogenous intoxication in pregnant women with inflammatory processes in the periodontium. The obtained data of ration between leukocytes and ESR (ILESR) in pregnant women with inflammatory lesions of periodontal tissues confirm the presence of intoxication. Similarly to LII index, ILSHOE increases by 9.94 times by the third trimester of pregnancy. It is likely that such a change may indicate the nature of autoimmune pathological processes during the gestational period. Average parameters of granulocyte-lymphocytic index (ILH) significantly decreased from I to III trimester by 6%, which allows us to differentiate autointoxication and infectious intoxication. Analysis of shift index of leukocytes (SIL) in pregnant women with gingivitis showed a slight increase of 5.6% in the second trimester and data values retention to the time of childbirth that may indicate inflammation activity and violations of immunological reactivity. Index of the ratio of neutrophils and lymphocytes (ISNL) from I to III trimester increased by 6.7%. A statistically significant increase in performance index value of neutrophils and monocytes (ISNM) by 1.2 times from the beginning to the third trimester of pregnancy may indicate activation of nonspecific inflammatory process. It should be noted that other integral indices were statistically and clinically less significant.

hematological indices, pregnancy gingivitis, generalized periodontitis

• 1. Дудченко М. А. Состояние язвенного стоматита и дуоденальной язвы у больных по интегральным гематологическим индексам / М. А. Дудченко, Л. В. Малик // Вісник проблем біології та медицини. – 2013. – Т. 2. (99), № 1. – С. 100-103.
• 2. Кальф-Калиф Я. Я. О „лейкоцитарном индексе интоксикации” и его практическом значении (сообщение первое) / Я. Я. Кальф-Калиф // Врачебное дело. – 1941. – № 1. – С. 31-35.
• 3. Мустафина Ж. Г. Интегральные гематологические показатели в оценке иммунной реактивности организма у больных с офтальмологией / Ж. Г. Мустафина, Ю. С. Крамаренко, В. Ю. Кобцева // Клиническая лабораторная диагностика. – 1999. – № 5. – С. 47- 49.
• 4. Орехова Н. С. Интегральные гематологические индексы при гингивите у беременных / Н. С. Орехова, Е. Л. Цепова // Пародонтология. – 2007. – № 2. – С. 9-11.
• 5. Орехова Н. С. Медико-социальные особенности гингивита у беременных: автореф. дис. на соискание науч. степени канд. мед. наук: спец. 14.00.21 „Стоматология” / Н. С. Орехова. – Смоленск, 2007. – 22 с.
• 6. Солдатов А. А. Расчетный индекс лейкоцитов в оценке аллергического процесса / А. А. Солдатов, А. В. Соболев, М. В. Берензон [и др.] // Клиническая лабораторная диагностика. – 1997. – № 11. – С. 35-36.

«Bulletin of problems biology and medicine» Issue 1 part 1 (126), 2016 year, 360-363 pages, index UDK 616.314.17-002.2-08