Mukvych V. V., Liashenko V. P., Lukashov S. M.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The age-related modulation of bioelectric activity of the ergotropic zone of the hypothalamus in male rats has been studied. Experiments were carried out on non-linear white outbred male rats of juvenile puberty period, young age of the reproductive period, mature age of the reproductive period, presenile age of the pronounced senile changes period. Animals of these groups were under standard care conditions, had normal diet and free access to drinking water. Our studies have shown that age-related changes of variation of normalized capacities of high-frequency and low-frequency components of Electric Hypothalamus Test (EGtG) occur in the ergotropic zone of the rat hypothalamus. Juvenile male rats, unlike young male rats, who have been characterized by a predominance of high-frequency oscillations (alpha and beta activity), have shown an almost equal distribution between the mentioned EGtG components. Instead, with age the dynamics of the EGtG components distribution becomes quite the opposite with peculiar predominance of low-frequency oscillations. In particular, this applies to adult rats. Despite the rather radical changes in the predominance of this or thе EGtG component in the ergotropic zone of the hypothalamus in rats of previous age groups, variation in the distribution of spectral capacities of male rats of the presenile age stabilizesand becomes almost identical with that of the juvenile male rats. We observed the corresponding distribution of highfrequency and low-frequency oscillations in juvenile, young and mature male rats with a decrease in their absolute capacity. Presenile male rats are characterized by an increase in the absolute capacity of the delta activity by 3.3 times, theta activity by 2 times, alpha activity by 9 times, beta-activity by 4.5 times compared with mature male rats. It is shown that with age, the dynamics of normalized capacities of the frequency EGtG components, deviated from the ergotropic zone of the hypothalamus, significantly changes. Juvenile male rats had almost equal distribution between high-frequency and low-frequency oscillations. Young male rats had been characterized by the highest rates of beta activity (57.54±3.23 %), prevalence of high-frequency oscillations and therefore desynchronization was observed. The bioelectric activity of the ergotropic zone of the hypothalamus in mature male rats was represented by slow-wave synchronization processes, where the highest percentages were registered in the delta range (49.03±8.6 %). In presenile male rats a sharp increase in alpha activity (30±3.5 %) by 1.9 times was observed as compared with young and mature rats. We believe that the results of the study on age-related modulation of bioelectric activity of the ergotropic zone of the hypothalamus in male rats reflect adaptive-compensatory changes in central neurotransmission in general.

ergotropic zone of the hypothalamus, Electric Hypothalamus Test (EGtG), normalized capacities of bioelectric activity, male rats, age

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«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 201-206 pages, index UDK 612.82:612.66:599.323.45

10.29254/2077-4214-2018-2-144-201-206