Ryzhkin D. V., Bumeister V. I.

AGE-RELATED CHANGES IN THE MORPHOLOGY OF THE SMALL INTESTINE DURING INTERMITTENT FASTING

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About the author:

Ryzhkin D. V., Bumeister V. I.

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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

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Scientific article

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The article analyzes current scientific data on morphological changes in the small intestine under various intermittent fasting (IF) protocols, taking age-related aspects into account. The findings reveal significant age- dependent differences in intestinal responses: young organisms exhibit adaptive epithelial hyperplasia and enhanced functional activity; mature organisms show more moderate adaptive changes accompanied by autophagy activation; elderly organisms demonstrate limited adaptive potential with a risk of atrophic alterations. The effectiveness and safety of IF strongly depend on age and the chosen protocol, emphasizing the need for age-specific recommendations.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 61-63 pages, index UDC 612.33:612.392:591.3

DOI:

10.29254/2523-4110-2025-4-179/addition-61-63