Rodynsky O. G., Voichenko Ya. S., Bibikova V. M., Guz L. V., Gninenko O. M.

LITERATURE REVIEWS

Scentific article

Today thyroid dysfunction is a current problem among the whole set of endocrine diseases. In this paper, a review of the literature on the influence of hyperthyroxinemia on behavioral activity and the state of the prooxidant and antioxidant systems in the brain structures of experimental animals, taking into account the age aspect. The role of excess T4 in the ontogenesis of rats is indicated, which causes considerable controversy in the scientific community, mainly due to the lack of thorough research on the mechanism of influence on behavioral activity and the state of prooxidant and antioxidant systems. The actual characteristics of the connection between hyperthyroxinemia and oxidative stress in the structures of the brain are presented. The functional features of the enzymatic component and participation in the implementation of a complex neurochemical system under conditions of deficiency of components of the cellular composition of the CNS are emphasized. Particular attention was paid to the analysis of data found in the open field test, also compared, taking into account the age aspect, the current results of behavioral reactions in juvenile, young and old rats related to changes in the number and duration of stays in the sleeves; the role of CNS mediators (serotonin, GABA, glutamate) is generalized in this. Current literature does not provide a definitive answer on the degree of susceptibility to anxiogenic effects and changes in resistance to anxiety (resulting from the action of thyroid hormones on rats during behavioral testing), and data on thyroid dysfunction of the combined effect of antioxidant balance sufficient and remain unfinished issues of their coverage for society as a whole.

hyperthyroxinemia, behavioral activity, antioxidant system, rats of different ages, ontogenesis.

1. Pobihun NG. Kaltsii-fosfornyi balans u shchuriv iz hipofunktsiieiu shchytopodibnoi zalozy pry fizychnomu navantazhenni, stresi ta yikh poiednanni [dysertatsiia]. Ivano-Frankivsk: Ivano-Fr. nats. med. un-t; 2015. 164 s. [in Ukrainian].
2. Kim KI, Dimitrova DO, Katamadze NN, Dzantiieva TS, Piharova KO. Vplyv endohennykh i ekzohennykh faktoriv na imunolohichni testy otsinky funktsii shchytopodibnoi zalozy. Klinichna i eksperymentalna tyreoidolohiia. 2020;16(3):16-24. [in Russian].
3. Rodynskyi OG, Demchenko OM, Kondratieva OYu, Rodynska HO, Kirichenko SV. Anksiolitychnyi efekt tyreoidnykh hormoniv. Ukrainskyi zhurnal medytsyny, biolohii ta sportu. 2018;3(5):306-0. [in Ukrainian].
4. Niedowicz DM, Wang WX, Price DA, Nelson PT. Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes. J Thyroid Res. 2021 Jun 24;2021:9960188. DOI: 10.1155/2021/9960188.
5. Riabukha OI. Deiaki aspekty vplyvu shchytopodibnoi zalozy na stan orhanizmu v umovakh normy i patolohii. Aktualni problemy suchasnoi medtsyny: VISNYK Ukrainska medychna stomatolohichna akademiia. 2018;18(3):324-8. [in Ukrainian].
6. Alvarez-Crespo M, Csikasz RI, Martínez-Sánchez N, Diéguez C, Cannon B, Nedergaard J, et al. Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance. Mol Metab. 2016 Feb 10;5(4):271-282. DOI: 10.1016/j.molmet.2016.01.008.
7. Ahmed OM, Ahmed RG, El-Gareib AW, El-Bakry AM, Abd El-Tawab SM. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II—The developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. Int J Dev Neurosci. 2012 Oct;30(6):517-37. DOI: https://doi.org/10.1016/j.ijdevneu.2012.04.005.
8. Viktorova AF, Pokhmelnova MS, Kuleshova OM. Povedinka samtsiv bezporodnykh shchuriv u testi “vidkryte pole” pry hiperfunktsii ta hipofunktsii shchytopodibnoi zalozy. Pryrodnychi nauky. 2018;4(65):24-9. [in Russian].
9. Molehin D, Nitert DM, Richard K. Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism. Journal of Thyroid Research [Internet]. 2016 [cited 2022 Jan 19];2016:1-14. Available from: hindawi.com/journals/jtr/2016/8765049. DOI: 10.1155/2016/8765049.
10. Razvi S, Bhana S, Mrabeti S. Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction. J Thyroid Res. 2019 Sep 22;2019:4106816. DOI: 10.1155/2019/4106816.
11.  Dmytryshyn YaD. Analiz faktoriv psykhoemotsiinoho navantazhennia v molodykh liudei, yaki prozhyvaiut na terytorii pomirnoho yododefitsytu. Materialy nauk.-prakt. konf. z mizhnarodnoiu uchastiu Fiziolohichni ta klinichni aspekty endokrynnoi patolohii; 2019 Zhovt 17-18; Yaremche. Ivano-Frankivsk: Ivano-Fr. nats. med. un-t; 2019. s. 33-4. [in Ukrainian].
12. Stetseviat VB. Antyoksydantnyi rezerv syrovatky krovi insulinorezystentnykh shchuriv iz nabutym i vrodzhenym yododefitsytom. Materialy nauk.-prakt. konf. z mizhnarodnoiu uchastiu Fiziolohichni ta klinichni aspekty endokrynnoi patolohii; 2019 Zhovt 17-18; Yaremche. IvanoFrankivsk: Ivano-Fr. nats. med. un-t; 2019. s. 62. [in Ukrainian].
13. Kamilova IK, Myklin OP, Zinchenko OO, Hudz OV. Hipertyreoz u zhinok reproduktyvnoho viku. Ohliad literatury. Materialy XVII mizhnarodnoi naukovo-praktychnoi konferentsii Aktualni pytannia suchasnoi nauky; 2018 Hrud 19; Ufa. Simferopol: KFU im. V.I. Vernadskoho; 2018. s. 86-91. [in Ukrainian].
14. Tedeshi L, Vassalle C, Vervasi G, Sabatino L. Main Factors Involved in Thyroid Hormone Action. Molecules [Internet]. 2021 [cited 2022 Jan 19]; 26(23):7337. Available from: mdpi.com/1420-3049/26/23/7337/htm. DOI: 10.3390/molecules26237337.
15. Huz LV. Neirometabolichni osoblyvosti ta intehratyvna diialnist tsentralnoi nervovoi systemy za umov eksperymentalnoi hipertyroksynemii u shchuriv [avtoreferat]. Kharkiv: Kharkiv. nats. un-t; 2008. 22 s. [in Ukrainian].
16. Nandi A, Yan LJ, Jana CK, Das N. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases. Oxid Med Cell Longev. 2019 Nov 11;2019:9613090. DOI: 10.1155/2019/9613090.
17. Costilla M, Macri Delbono R, Klecha A, Cremaschi GA, Barreiro Arcos ML. Oxidative Stress Produced by Hyperthyroidism Status Induces the Antioxidant Enzyme Transcription through the Activation of the Nrf-2 Factor in Lymphoid Tissues of Balb/c Mice. Oxid Med Cell Longev. 2019 Jun 2;2019:7471890. DOI: 10.1155/2019/7471890.
18. Arriagada AA, Albornoz E, Opazo MC, Becerra A, Vidal G, Fardella C, et al. Excess iodide induces an acute inhibition of the sodium/ iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology. 2015 Apr;156(4):1540-51. DOI: 10.1210/ en.2014-1371.
19. Gargouri B, Mseddi M, Mnif F, Abid M, Attia H, Lassoued S. Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease. J Clin Lab Anal. 2020 Feb;34(2):e23051. DOI: 10.1002/jcla.23051.
20. Muzyka VV, Menshanov PN, Bannova AV, Dyhalo NN. Vzaiemozviazok BDNF ta yoho proformy z rivnem aktyvnoi kaspazy-3 u viddilakh holovnoho mozku neonatalnykh shchuriv. Neurochemical journal. 2012;29(4):278-82. [in Russian].
21. Halkina OV. Osoblyvosti vilnoradykalnykh protsesiv i antyoksydantnoho zakhystu dorosloho mozku. Neurochemical journal. 2013;30(2):93- 102. [in Russian].
22. Rodrigues TB, Ceballos A, Grijota-Martínez C, Nuñez B, Refetoff S, Cerdán S, et al. Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter Slc16a2 (Mct8). PLoS One. 2013;8(10):e74621. DOI: 10.1371/journal. pone.0074621.
23. Schroeder CA, Privalsky ML. Thyroid hormones, T3 and T4, in the brain. Front. Endocrinol. 2014 March 31;5(40):1-6.
24. Morte B, Gil-Ibañez P, Heuer H, Bernal J. Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad. Thyroid. 2021 Jun;31(6):985-993. DOI: 10.1089/thy.2020.0649.
25. Blynov DV, Terentiev OO. Kharakterystyka biokhimichnykh markeriv porushennia hematoentsefalichnoho barieru i funktsionuvannia tsentralnoi nervovoi systemy. Neurochemical journal. 2013;30(3):179-92. [in Russian].
26. Zhukov DA, Vynohradova KP. Slidovi aminy i povedinka. Neurochemical journal. 2020;37(4):311-17. [in Russian].
27. Cherepovska NO, Zhunusov NS, Miller ES. Vyvchennia povedinkovoi aktyvnosti u testi “vidkryte pole”. Naukovyi elektronnyi zhurnal «Merydian». 2020;4(38):84-7. [in Russian].
28. Hostiukhina OA, Zamoshchyna TA, Svietlin MV, Zhukova OB, Zaitsev KV, Abdulkina NH. Povedinkova aktyvnist shchuriv u vidkrytomu poli pislia svitlovoi chy temnovoi depryvatsii i fizychnoi perevtomy. Biuleten sybirskoi medytsyny. 2016;15(3):16-23. [in Russian].
29. Abdulkina NH, Zaitsev KV, Zhukova OB, Hostiukhina OA, Vorobiov VA, Zaitsev AA. Oriientovno-doslidnytska povedinka u shchuriv pry vibratsiino-shumovii dii. Journal of Siberian Medical Sciences. 2015;2015(6):52. [in Russian].
30. Koviazina TK, Lobastova OV, Ulitko MV. Doslidzhennia vplyvu novoi khimichnoi spoluky na povedinkovu khimichnu aktyvnist tvaryn riznoi stati metodom “vidkryte pole”. Yevraziiskyi Soiuz Vchenykh. 2015;6(15):103-7. [in Russian].
31. Hevorkian VS, Hevorkian IS. Suchasne doslidzhennia vplyvu riznykh stres-faktoriv na shchuriv i myshei. Elektronne naukove vydannia Almanakh Prostir i chas. 2017;15(1):1-21. [in Russian].
32. Demchenko OM, Rodynskyi OG, Kondratieva OYu, Zaichenko OYu. Rol tyreoidnykh hormoniv u formuvanni prostorovoi pamiati shchuriv u rannomu ontohenezi. Fiziol. zhurn. 2021;67(2):22-30. [in Ukrainian].
33. Demchenko OМ. Psykho-emotsiinyi status shchuriv za umov dysfunktsii shchytovydnoi zalozy. Medychni perspektyvy. 2014;19(14):10-5. [in Ukrainian].
34. Marcelino TB, Longoni A, Kudo KY, Stone V, Rech A, de Assis AM, et al. Evidences that maternal swimming exercise improves antioxidant defenses and induces mitochondrial biogenesis in the brain of young Wistar rats. Neurosci. 2013 Aug 29;246:28-39.
35. Kurianova YeV, Ukad OS, Zhukova YuD. Polovyye i tipologicheskiye razlichiya povedencheskoy aktivnosti nelineynykh krys v teste «Otkrytoye pole». Sovremennyye problemy nauki i obrazovaniya. [Internet]. 2013 [cited 2022 Yanv 19];5:1. Dostupno: https://scienceeducation.ru/ru/article/view? id=10029. [in Russian].
36. Kondratieva OYu. Vikovyi aspekt neiromediatornoho mekhanizmu formuvannia kohnityvnoi aktyvnosti za umov dysfunktsii shchytopodibnoi zalozy [dysertatsiia]. Dnipro: Dnipro med. un-t; 2020. 120 s. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 1 (163), 2022 year, 62-66 pages, index UDK 616.831:616.44]-008.6-053-092.9:612.397

10.29254/2077-4214-2022-1-163-62-66