Leush S. S., Vitovskyi Y. M.

A NON-INVASIVE WAY TO CALCULATE CIRCULATING BLOOD VOLUME IN PREGNANT WOMEN

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About the author:

Leush S. S., Vitovskyi Y. M.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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Physiological hemodilution accompanies the entire course of pregnancy, adding at least 30% of the blood volume into the circulation. Many pathological processes in obstetrics are based on hypovolemia as a consequence of insufficient hemodilution. The possibilities of volemic disorders diagnosing in obstetrics are limited due to the invasiveness of the methods. The aim of the study was to evaluate the effectiveness of the calculation method for determining the volume of circulating blood in pregnant women. The study was performed on the basis of medical history records analysis. CBV was calculated in the dynamics of pregnancy development in patients after extremely preterm birth (22-27 weeks – 30 medical records), after moderate preterm birth (28-34 weeks – 37 records) and after full-term delivery at 37-41 weeks – 40 records. The examination data were selected from women with spontaneous first singleton births, with an incomplicated obstetric and somatic anamnesis. The Liljestrand-Zander formula was used to calculate the value of CBV in pregnant women. CBV parameters at 10-12 weeks were similar in all groups: 3325.4±371.32; 3140.8±583.69 and 3290.6±294.62 ml. The estimated CBV value of pregnant women of the EPB group lagged behind the values in the MPB and FT groups from the period of 13-15 weeks. In the MPB group, the indicators were close to the values of the FT group, but sharply decreased in this group from 4091.6±238.41 to 3518.3±158.39 (ml) at the birth time (p˂0.05). The increase in CBV continued uniformly until the birth in the FT group. Conclusions. 1. The calculated method of determining the circulating blood volume in the pregnancy progression can be an additional safe way to monitoring the condition of a pregnant woman due to its convenience and non-invasiveness. 2. Women who gave birth prematurely, had signs of a reduced circulating blood volume in the dynamics of pregnancy progression. 3. The peculiarities of the dynamics of changes in blood volume in extremely preterm and moderate preterm birth may reflect a different causes and mechanisms of premature labor.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 409-417 pages, index UDC 618.2/.3-071:616.151.1

DOI:

10.29254/2077-4214-2024-4-175-409-417