Sukmanskaya G. D., Yura A. M.

SENSITIVITY OF THE PATHOGENS, CAUSING ORAL CANDIDASIS, TO ANTIMICROBIAL AGENTS

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About the author:

Sukmanskaya G. D., Yura A. M.

Heading:

MICROBIOLOGY

Type of article:

Scientific article

Annotation:

Oral candidiasis is one of the most common opportunistic infections today. This is due to the significant spread of yeast-like fungi in the human population, especially among older people and children, the increase in the influence of such risk factors as adverse environmental factors, uncontrolled use of antibiotics, etc., leading to dysbiotic shifts. The pharmaceutical market offers a wide range of antifungal agents. For the treatment of oral candidiasis, foreign clinical protocols envisage the use of different treatment regimens, depending on the severity of the infection and the sensitivity of the pathogens, which include antimycotics of various chemical groups (polyenes, triazoles, echinocandins, imidazoles). In Ukraine, there has been no update of the national protocols for treating candidiasis of the oral mucosa based on the results of monitoring the sensitivity to antimycotics of Candida spp. The study aimed to determine the sensitivity of clinical isolates of Candida spp., isolated from patients with manifestations of candidal lesions of the oral mucosa, to the most widely used in domestic clinical practice antimycotics and surface-active antiseptics. As a result of a microbiological study of 58 samples of clinical material, 28 clinical strains of yeast-like fungi of the genus Candida were isolated, of which 25 strains were identified as Candida albicans (89.3%) and 3 isolated cultures were identified as Candida krusei (10.7%). The results of determining the sensitivity of the obtained isolates of Candida spp. to antimycotics, it was possible to establish a high level of resistance to fluconazole, voriconazole, nystatin, about half of the strains were resistant to itraconazole, terbinafine, amphotericin B. The least resistant isolated Candida albicans were clotrimazole (32% of isolated strains). The researched cultures of yeast-like fungi demonstrated a high level of sensitivity to surface-active antiseptics decamethoxine, chlorhexidine bigluconate and benzalkonium chloride, which allows the recommendation of these drugs for use in local oral candidiasis treatment regimens. The results of the conducted study confirm the need for constant monitoring of the sensitivity of circulating strains of oral candidiasis to the available arsenal of antimycotics.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 376-385 pages, index UDC 611.311:615.035.1+615.282.84:616.992.282

DOI:

10.29254/2077-4214-2023-3-170-376-385